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However, understanding these relationships is not straightforward because price, smokers motivation to change, and access to additional support (e.g., medication) are important factors in pack size choice and smoking behavior

Dr Ram Moorthy, deputy chair of the BMA's board of science, said: "Tighter controls are needed to ensure their use does not undermine current tobacco control measures and reinforces the normalcy of smoking behaviour." That same concern has prompted ministers in Wales to have a public consultation on how to tackle e-cigarettes, including the possible first ban in the UK on their use indoors

Interestingly, the harmala alkaloids have been dubbed by studies as having neuroprotective, anti-cancer properties, contradictory to many studies done on tobacco smoking

VELOZYN Who should choose VELO, who should choose ZYN Choose VELO if: You want immediate flavour activation and a pronounced nicotine presence from the first minutes of a session

Data availability Data inputs were derived or obtained from publicly available data or published sources and are detailed with citations in the manuscript and supplement